![]() Nonclinical Toxicology Carcinogenesis, Mutagenesis, Impairment Of Fertility Use With Contact LensesĬontact lenses should be removed prior to instillation of Avatan Z ® and may be reinserted 15 minutes following its administration. These containers had been inadvertently contaminated by patients who, in most cases, had a concurrent corneal disease or a disruption of the ocular epithelial surface. There have been reports of bacterial keratitis associated with the use of multiple-dose containers of topical ophthalmic products. Angle-Closure, Inflammatory Or Neovascular GlaucomaĪvatan Z ® has not been evaluated for the treatment of angle-closure, inflammatory or neovascular glaucoma. Avatan Z ® should be used with caution in aphakic patients, in pseudophakic patients with a torn posterior lens capsule, or in patients with known risk factors for macular edema. Macular edema, including cystoid macular edema, has been reported during treatment with travoprost ophthalmic solution. Intraocular InflammationĪvatan Z ® should be used with caution in patients with active intraocular inflammation (e.g., uveitis) because the inflammation may be exacerbated. Eyelash changes are usually reversible upon discontinuation of treatment. These changes include increased length, thickness, and number of lashes. Eyelash ChangesĪvatan Z ® may gradually change eyelashes and vellus hair in the treated eye. While treatment with Avatan Z ® (travoprost ophthalmic solution) 0.004% can be continued in patients who develop noticeably increased iris pigmentation, these patients should be examined regularly. Neither nevi nor freckles of the iris appear to be affected by treatment. Typically, the brown pigmentation around the pupil spreads concentrically towards the periphery of the iris and the entire iris or parts of the iris become more brownish. Iris color change may not be noticeable for several months to years. The long-term effects of increased pigmentation are not known. Patients who receive treatment should be informed of the possibility of increased pigmentation. After discontinuation of travoprost, pigmentation of the iris is likely to be permanent, while pigmentation of the periorbital tissue and eyelash changes have been reported to be reversible in some patients. The pigmentation change is due to increased melanin content in the melanocytes rather than to an increase in the number of melanocytes. ![]() Pigmentation is expected to increase as long as travoprost is administered. The most frequently reported changes have been increased pigmentation of the iris, periorbital tissue (eyelid) and eyelashes. ![]() Travoprost ophthalmic solution has been reported to cause changes to pigmented tissues. The entire process is a pure joy.Included as part of the "PRECAUTIONS" Section PRECAUTIONS Pigmentation The intuitive and convenient interface makes it possible to implement complex processing in simple steps. Thus, the range of opportunities offered by the photo editor is constantly growing. Every second an enormous number of users add new effects and resources for editing images on a variety of themes, replenishing their collections. Due to these multiple options, your edited photos will always be of high quality and special style. You can save your favorite effects and resources to apply them later while editing your new photos. This makes it possible to always easily eliminate any imperfections with high quality. Moreover, the photo editor features embedded functions for all the necessary types of face retouching and body shape adjustment. You can add and use 4 various resources when editing images: To create effects, you can use various tools and resources. You have the opportunity to create and save your own, customized effects. It enables people to edit photos interacting with each other, while using their own processing elements.Īll the elements are created and added by users to the social network integrated with the photo editor.
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